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Reactive oxygen species: a novel antimicrobial

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Some new linkers with novel mechanisms are also under development, including linkers that utilize exogenous triggers for payload release, which has become a new direction in cleavable linker development

Moreover, inhibition of autophagy combined with irradiation induces a potent antitumor effect in PD-L1-deficient lung cancer mouse models via cGAS-STING-mediated T-cell activation, suggesting a possible combination therapy of irradiation, anti-PD-L1 immune checkpoint blockade and autophagy inhibition in patients with lung cancer (218)